USB drives are mostly meant to transfer files from one computer to another when you don’t have any other alternative. But while transferring files, your USB drive is likely to get infected if the other computer has virus in it.
Thumbscrew is a small utility which will make your USB drive write protected (you can’t write anything) if you need to use it on a computer that is infected from those viruses and running Microsoft Windows XP/Vista.
You can either write Thumbscrew on any CD or DVD or can directly download it form the internet if you have access on infected machine.
After you run Thumbscrew, on your tray right click on its icon and select “Make USB Readonly” and then insert your USB pen drive. It won’t get infected now.

Thanks for this info. I’ve been looking for ways to protect my thumb drive, it has my most important files and I can’t quite imagine what would happen if I’d lost them to a virus!
Arlene, I would suggest you to backup those important files on the web. You never know ..